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KMID : 0377519970220030127
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Chung-Ang Journal of Medicine
1997 Volume.22 No. 3 p.127 ~ p.136
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Expression of the steroid receptors and the p53 and bcl-2 protein in invasive duct carcinoma of the breast
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Paeng Sung-Sook
Park Eon-Sub
Kang Eung-Taek
Yoo Jae-Hyung
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Abstract
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This study was conducted to evaluate the expression of p53 and bcl-2, known as important prognostic factors of breast carcinoma, using immunohistochemical method in 64 invasive duct carcinoma, and the correlation with steroid receptors including estrogen (ER) and progesteron receptors (PR). The results were as follow; 1. The frequency of steroid receptor positivity in invasive duct carcinoma by four prognosic group was 18 cases(28.1%) in ER(+) and PR(+) group, 18 cases(28.1%) in ER(+), PR(-) group, 6 cases (9.4%) in ER(-) and PR(+) group, and cases (34.4%) in ER(-) and PR(-) group. 2. The immunohistochemical association between p53 and steroid receptor showed 28.6% & p53 expression in steroid receptor positive group and 54.3% & p53 expression in steroid receptor negative group. However, the statistical significance was not present. 3. A positive relationship was seen between bcl-2 and steroid receptor was statistically significant, presenting 76.2% bcl-2 expression in steroid receptor positive group and 45.5% bcl-2 expression in steroid receptor negative group. 4. The frequency of p53 and bcl-2 expression in invasive duct carcinoma was 14 cases(21.9%) in p53(+), bcl-2(+) group, 8 cases(12.5%) in p53(+) and bcl-2(-) group, 26 cases(40.6%) in p53(-) and bcl-2(+) group, and 16 cases(25%) in p53(-), bcl-2(-) group.
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KEYWORD
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Stroid receptor, p53, bcl-2 oncoprotein, invasive duct carcinoma, breast
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